Google Scholar Research Frans Bianchi is a biochemist studying the intracellular trafficking and immune presentation of antigenic membrane proteins.
The metabolic dialogue between the microbiota and host cells involves small molecule signaling metabolites, peptides and proteins. Temporal and spatial interplay of microbiota and intestinal mucosa drive establishment of immune homeostasis in conventionalized mice.
We hypothesize that the gut microbiota can metabolize neuro-amines produced from the host and its diet to subsequently produce neuroactive metabolites, thus contribute to signaling to the host gut-brain axis.
Finally, he compared transport fluxes of eukaryotic and prokaryotic basic amino acid transporters using reconstituted proteins in proteo-liposomes with radioactively labeled substrate.
Featured in Chemisch2Weekblad Dutch. Previously, we have identified the molecular mechanisms involved in the reprogramming of the intestinal mucosal immune responses to initiate and maintain a balanced immune response.
Furthermore, he identified that steric interactions of large cytosolic domains form the predominant barrier of this impaired lateral diffusion. The microbiota and the gut-brain axis: During his PhD, Frans studied the mobility, oligomerization and localization of plasma membrane-incorporated amino acid transporters in budding yeast using advanced microscopy and spectroscopy techniques single particle tracking, super-resolution microscopy, circular dichroism.
The gut microbiota elicits a profound metabolic reorientation in the mouse jejunal mucosa during conventionalisation. This so-called microbiota has co-evolved with man to perform a number of beneficial functions; these extend beyond the gastrointestinal tract to influence host behaviour and mental health.
These signaling molecules, such as neuroactive chemicals, in particular neuro-amines, seem to play a key role in shuttling information between the host and its microbiota. In a recent bioinformatics study Frans and coworkers revealed that MHC-I epitopes are several-fold enriched in transmembrane helices depending on the haplotype.
Colonization of the gut microbiota launches complex communication networks with the host immune, metabolic and neuroendocrine systems, which ultimately impacts the overall wellbeing of the host organism 6.
Similarly, we revealed that only the establishment of a balanced microbial community could deplete high-energy metabolites and generate second-stage fermentation short chain fatty acids that can be efficiently metabolised by colonic epithelia 3.
The latest updated list of publications by Frans Bianchi can be found here. He showed that the localization of these plasma membrane proteins in S. Research outline aiming to unravel To test our hypothesis, we address 3 main questions summarised in figure 3-for details see the potential projects within Join the lab: Can the gut microbiota metabolize these neuro-amines?
Unravelling the Multidirectional Axes of Communication. The gradual development of the adaptive immune system appeared to follow a strong but transient hyper-induction of innate immune responses, including high-level production of antimicrobial peptides1, 2.Mucosa Drives Establishment of Homeostasis in Conventionalized Mice.
Sahar El Aidy.
Thesis committee. Thesis supervisor.
Sahar El Aidy Thesis. in public on Friday 17 February at 4 p.m. in the Aula. Sahar El Aidy. The dynamic interplay of microbiota and mucosa drives establishment of homeostasis in conventionalized mice, pages.
Research Sahar El Aidy. The human intestine harbours the majority of the body’s microbes. This so-called microbiota has co-evolved with man to perform a number of beneficial functions; these extend beyond the gastrointestinal tract to influence host behaviour and mental health.
Dr. Sahar El Aidy (Wageningen University) Wageningen University to start her Ph.D. thesis under the supervision of Professor Michiel Kleerebezem.
The Ph.D. project was a work-package within one of the Top Institute of Food and Nutrition projects. Title: Guestseminar_Sahar El Aidy. sahar el aidy thesis types of essay with definition %A El Aidy,Sahar %A Dinan,Timothy %A Cryan,John %D %J Frontiers in Microbiology %C %F %G English %K Neuropeptides.
hum week 1 assignment stages of critical thinking PhD thesis: “Probiotic Willy Verstraete, Sahar El Aidy, Annelies Geirnaert and Tom Van de Wiele.
Website of the laboratories of Geert van den Bogaart and Sahar El Aidy at the University of Groningen studying molecular immunology and host-microbe biology. Sahar El Aidy's 9 research works with citations and 1, reads, including: The Role of Supplemental Complex Dietary Carbohydrates and Gut Microbiota in Promoting Cardiometabolic and.Download